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Postdoc in Integrative Physiology and Proteomics

Novo Nordisk Foundation Center for Basic Metabolic Research
Faculty of Health and Medical Sciences
University of Copenhagen
 
We are looking for a highly motivated and dynamic researcher for a postdoc position. The start date is 1 March 2019.
 
Background
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) was established in 2010 to conduct fundamental research on metabolism. It is part of the Faculty of Health and Medical Sciences, University of Copenhagen. The Center has around 170 employees from all over the world. Its employees moved into new laboratories, offices and meeting rooms in the Maersk Tower in summer 2017. You can read more about us at http://cbmr.ku.dk.  
 
The current position is in the Program for Integrative Metabolism and Environmental Influences headed by Professor Juleen R. Zierath. The laboratory of Juleen R. Zierath is aiming at expanding a multidisciplinary team of physiologists and bioinformaticians to perform multi-omics investigations. He or she will be embedded in the Center and work in a scientific environment that bridges several disciplines of proteomics and metabolic diseases. The selected candidate is expected to interact with staff at all levels, both internally and externally, regarding relevant research topics.
 
Project description
Physical exercise provides numerous salutary effects against various chronic diseases, but the understanding of the mechanistic basis for the health benefits of exercise remains limited. Exercise improves the detrimental effects of obesity, prevents or delays the onset of type 2 diabetes (T2D), and has other metabolically beneficial effects in both non-healthy and healthy individuals. The immune system, and more specifically secreted and circulating immune-related factors, partly account for these salutary effects. Given their beneficial effects on whole body metabolism, they have been proposed for human therapeutic use in metabolic diseases including T2D. The scientific community has not yet identified the full range of secreted factors (named “myokines”) in response to muscle contraction and exercise.
 
Profile
We are seeking a highly motivated researcher who will use state-of-the-art proteomics technology to identify secreted factors in response to physical exercise. The project includes detailed investigations of selected secreted factors and their potential role in whole body metabolism.
 
Essential criteria
  • PhD in biochemistry, molecular biology, cell biology, physiology, or related science  
  • Documented expertise in high resolution mass spectrometry and proteomics sample preparation  
  • Documented hands-on experience with Thermo HFX mass spectrometers and Thermo nLC 1200 systems  
  • Documented experience with bioinformatics proteomics data analysis (i.e., MaxQuant and Perseus software)  
  • Previous experience with animal handling and murine in-vivo experiments (IGTT, OGTT, ITT, treadmill and wheel exercise, dissections, etc.) (i.e., FELASA C certification or equivalent)  
  • Prior experience in molecular and cellular biology experiments, such as immunoblotting, siRNA, qPCR, ELISA sandwiches, glucose uptake and fatty acid oxidation assays in cellular models  
  • Knowledge of skeletal muscle biochemistry and physiology  
  • Proven track record showing continuous scientific productivity in peer reviewed journals  
  • Excellent written and oral communication skills in English  
  • Independent thinking, and analytical aptitude for devising innovative scientific or technical solutions  
  • Demonstrated capacity for effective team work  
  • Demonstrated enthusiasm, motivation, flexibility and confidence
Desirable criteria
  • Experience in Python or another programming language  
  • Experience in handling and processing large-scale scientific data  
  • Experience in experimental design, and planning of experiments  
  • Experience in mitochondrial respiration experiments (Seahorse and Oroboros experiments)  
  • Candidates with additional background in exercise physiology and bioenergetics would be highly regarded
Terms of employment
The employment as postdoc is a full time position for 3 years. Starting date is 1 March 2019. Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.
 
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
 
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.
 
Questions
For further information, please contact Professor Romain Barrès by email barres@sund.ku.dk.
 
International applicants may find the following links useful www.ism.ku.dk (International Staff Mobility) and https://www.workindenmark.dk/.  
 
Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:
  • Motivated letter of application addressing each of the essential criteria (max. one page)
  • CV including education, work/research experience, language skills and other skills relevant for the position
  • A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do
  • List of publications
  • List of three references
Application deadline is 19 December 2018, 23.59pm CET
 
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
 
The further process
After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then notified whether an unbiased assessor has passed their application for assessment. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
 
You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/
 
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
 
The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.
 
SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Romain Barrès

Info

Ansøgningsfrist: 19-12-2018
Ansættelsesdato: 01-03-2019
Arbejdstid: Fuldtid
Afdeling/Sted: Novo Nordisk Foundation Center for Basic Metabolic Research

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