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3-year PhD Fellowship in Computational Drug Design

The Computational Drug Design Group (Gloriam group), Department of Drug Design and Pharmacology, University of Copenhagen, and the company SARomics Biostructures, Lund, Sweden; wishes to employ a joint PhD Fellow in Scientific Database Development. The project starts 1. February 2018 and lasts for 3 years. 
 
Groups 
You will first train 1,5 years jointly with all 5 PhD Fellows at the University of Copenhagen. Subsequently, the last 1,5 years will be spent with together with the crystallography PhD student at SARomics. The employer SARomics is leading provider in commercial services for structure-based drug/ligand design, and has licenses for state-of-the-art software suite. 
 
The Gloriam group (gloriamgroup.org) conducts bioinformatics, scientific data analysis and computational drug design, tightly integrated with leading chemists and pharmacologists, and structure-function studies of G protein-coupled receptors (GPCRs) – one of the largest drug target families. The group also heads the GPCR community’s main database and web server, GPCRdb (GPCRdb.org) serving ~1700 monthly users. The group currently has 15 members, funded mainly by an ERC Starting Grant and Lundbeck Foundation Fellowship, and has in the last 1,5 years published in e.g. Nature, Nature Chemistry, Nucleic Acids Research and Bioinformatics. 
 
Project 
The PhD fellowships is one of five that are part of the EU-funded project, SAFER (www.safer-itn.eu). This is an ambitious interdisciplinary European Industrial Doctorates (EID) programme under the Horizon 2020 Marie Skłodowska-Curie Actions (MSCA-ITN-EID, Grant agreement: 765657), which offers positions with competitive salaries and family allowances. PhD students will obtain ample scientific, business and transferrable skills at excellent research environments meriting themselves for international academic or industrial careers.  
 
The ultimate scientific goal for the SAFER program is to gain molecular understanding and improve selectivity in treatments of CNS-related disorders. This will be done with a particular focus on the serotonin 5-HT2A receptor – the primary target for many pharmaceuticals and hallucinogens. SAFER will design and prepare ligands for the receptor, generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide further experiments.  This is fundamental to understand the biological and therapeutic effects, and to develop safer drugs. 
 
Qualification requirements 
Mandatory requirements 
  • A MSc in in computational chemistry, bioinformatics, molecular biology or similar topic 
  • Experience of data analysis 
  • Demonstrated ability to independently learn new concepts and solve biological problems 
  • Fluency in English and experience in writing scientific texts 
  • The candidate must have less than 4 years of research experience and must not have resided or carried out his/her main activity in Sweden for more than 12 months during the last 3 years immediately prior to the recruitment 
Additional meriting qualifications 
Experience of, and skills in: 
  • G protein-coupled receptors 
  • Analysis of molecular structures and interactions 
  • The Schrödinger Drug Discovery Suite, PyMOL 
  • Shell scripting, programming in Python or other languages, and web development 
Key criteria for the assessment of applicants 
  • Professional qualifications relevant to the project 
  • Relevant work experience 
  • Publications 
  • Other professional activities 
  • Language skills 
  • Good interpersonal skills 
Questions 
For further information about the post, please contact Associate Professor David E. Gloriam via david.gloriam@sund.ku.dk or (+45) 93 56 54 49; or Dr. Bo Svensson via bo.svensson@saromics.com
 
Application 
The application, in English, must be submitted in the online application form. The application must include the following appendices: 
Appendix 1: curriculum vitae with documentation of education. 
Appendix 2: a complete list of publications and list of submitted appendices. 
Appendix 3: documentation of additional research qualifications. 
 
In addition to the material the applicant wishes to be included in the assessment, the Assessment Committee may include further material in their assessment of the applicant, such as reference letters. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee. Following processing of the application, any application material sent will be destroyed. 
 
The applicant will be assessed according to the Ministry of Science Technology and Innovation Executive Order no 284 of 25. April 2008. 
 
University of Copenhagen and Denmark 
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 37,000 students and 9,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more at www.sund.ku.dk and www.drug.ku.dk.  
 
Copenhagen is a modern capital with plenty of opportunities in culture, design, architecture, restaurants and a diverse nightlife. At the same time, the city offers beaches, beautiful parks and green nature areas, and the Copenhageners bike everywhere. The Danish society prioritises a good work-life balance, and the work culture is well adjusted for families with children. Read more at http://ism.ku.dk/.  
 
SARomics Biostructures and Sweden 
SARomics Biostructures is based in Lund, Sweden, conveniently located in the heart of Medicon Valley, one of Europe's strongest biotech clusters. The company was founded in 2006 and is now the No 1 provider of protein 3D structure determination and structure-based drug discovery services in Scandinavia with access to world leading X-ray facilities in the MAX-IV laboratory. Read more at http://www.saromics.com/ 
 
Lund – The City of Ideas - is one of the oldest cities in Sweden dating back to 990, in addition to the 1,000 years of history Lund is a modern university city with a combination of businesses, students and researchers from around the world which form the unique character of the city. In Lund, you find the charm of a small picturesque, cobble-stoned city, side-by side with big city attractions such as services, shopping, restaurants and cultural events.  Lund has been voted the best place to live in Sweden. https://www.youtube.com/watch?v=Dc7PO9hoSKU 
SØG STILLINGEN

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Kontakt

David E. Gloriam

Info

Ansøgningsfrist: 20-10-2017
Ansættelsesdato: 01-02-2018
Arbejdstid: Fuldtid
Afdeling/Sted: SARomics Biostructures

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