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PhD fellowship on “Establishment of a haemophilia A model with increased tolerance by use of mice with deficiencies in adaptive immunity” at the LIFEPHARM Centre

Department of Veterinary and Animal Sciences  
Faculty of Health and Medical Sciences  
University of Copenhagen  
 
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen is offering a PhD fellowship commencing in April 2017 or as soon as possible thereafter.
 
Information about the department can be found at http://ivh.ku.dk/english/.
 
The Faculty of Health and Medical Sciences (SUND) and Novo Nordisk A/S established a research centre in 2010 - The LIFEPHARM Centre (www.lifepharm.dk) - with a total budget of DKK 78 million covering activities until the end of 2020.  
 
The present position is part of the Centre´s activities. The purpose of the research centre is to strengthen the research in experimental pharmacology and toxicology and to increase the output of candidates and PhDs with a strong in vivo pharmacological profile.  
 
It is expected that the future PhD fellow will be enrolled in the Graduate Programme for In Vivo Pharmacology and Experimental Animals (IVP) at SUND and participate actively in this network. The IVP Graduate Programme was established in 2006 as a collaboration between the Faculties of Life Sciences, Pharmaceutical Sciences and Health Sciences at the University of Copenhagen, University of Aarhus, and industrial partners; Novo Nordisk A/S, LEO Pharma and H. Lundbeck A/S; www.invivofarm.dk.
 
For more information on LIFEPHARM or IVP please contact:  
Professor Jens Lykkesfeldt  
Director of LIFEPHARM  
jopl@sund.ku.dk
Phone: (+45) 353 33163
 
Project description
Haemophilia A (HA) is a chronic bleeding disorder that requires life-long treatment. Current treatment options include recombinant or plasma derived human factor VIII (rFVIII). The major difficulties for efficient long-term treatment are anti-drug (i.e. anti-FVIII) antibody (ADA) development, which occurs in about 30% of patients1, the necessity of frequent i.v. infusions and the development of bleeding associated complications like knee and ankle arthropathy2. There is currently no appropriate model to investigate and characterise novel compounds for prophylactic treatment in HA. Moreover, the pathological role of immune cell subset in haemophilic arthropathy has not been thoroughly described.
 
The present PhD project aims to evaluate different methodologies for chronic treatment in pre-clinical HA models, using either immunomodulators or B and T cell deficient mice (Rag2-KO). Parameters such as bleeding phenotype, ADA development, PK and PD will be described. When a methodology for chronic studies has been established, immune cell subset will be either depleted or engrafted in F8-KORag2-KO mice with induced haemophilic knee arthropathy. In this setup the development and progression of haemophilic knee arthropathy will be monitored by histopathology, IHC and potentially µCT. Using these approaches, it will for the first time be possible to study the prophylactic potential of novel compounds for more than two weeks, and further it will be possible to dissect the immunopathology involved in haemophilic knee arthropathy in F8-KO mice.  
1Fallon et al J Thromb Haemostasis 2017 doi: 10.1111/jth.13886  
2Luck et al J. Am. Acad Orthop. Surg 2004; 12 234-245  
 
Principal supervisor  
Professor Søren Skov  
E-mail: sosk@sund.ku.dk
Direct Phone: (+45) 353 33126  
Faculty of Health and Medical Sciences  
University of Copenhagen  
 
Co-supervisors
Name: Thomas Lindebo Holm  
Email: THLH@novonordisk.com
 
Name: Peter Thygesen  
E-mail: PTT@novonordisk.com
 
Name: Kasper Almholt  
E-mail: KAHL@novonordisk.com
 
Required qualifications
  • MSc in a biological science, veterinary medicine, medicine or other equivalent degree  
  • A special interest and competencies in topics such as pharmacology, haemophilia, immunology and animal models  
  • High level of motivation, responsibility and flexibility  
  • Experience with handling of animals  
  • Highly enthusiastic, ambitious and team-oriented personality  
  • Excellent communication skills in English (written and oral)  
  • Function A/B/D (FELASA Category C) course in carrying out animal experiments
Preferred qualifications
  • Previous experience within in vivo pharmacology and animal research  
  • Knowledge of microbiota research and related techniques  
  • Biochemical laboratory competencies
General Job description 
Your key tasks as a PhD fellow at SUND are to:  
  • Manage, carry through and conclude on your research projects  
  • Actively participate in PhD courses  
  • Write scientific articles and finalise your PhD thesis  
  • Participate in international congresses  
  • Conduct a research stay at an institution abroad  
  • Teach and disseminate your research
We offer
  • The opportunity to work in a state-of-the-art, highly innovative and scientifically stimulating environment with ambitious colleagues 
  • Excellent training opportunities, both personally and professionally  
  • The opportunity to contribute with new knowledge to an exciting and fast-moving scientific field
Key criteria for the assessment of candidates
  • The grade point average achieved in relevant University degrees  
  • Professional qualifications relevant to the PhD programme  
  • Relevant work experience  
  • Previous publications  
  • Other professional activities  
  • Language skills
The successful candidate is also required to be resourceful and to possess good interpersonal skills.  
 
Formal requirements
The position is available for a 3-year period for applicants holding a relevant master´s degree.  
 
It is a prerequisite that the PhD candidate is enrolled as a PhD fellow at the Faculty of Health and Medical Sciences, University of Copenhagen according to the rules stipulated in "Bekendtgørelse nr. 18 af 14. januar 2008 om ph.d.-graden."  
 
Terms of employment
Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. Depending on seniority, the monthly salary begins around DKK 25.141 (ca. 3.374 EUR) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013).  
 
Questions
For further information contact Søren Skov, email: sosk@sund.ku.dk.  
 
Foreign applicants may find the following link useful www.ism.ku.dk (International Staff Mobility).  
 
General information about PhD programmes at the Faculty of Health and Medical Sciences is available on the Graduate School’s website: http://healthsciences.ku.dk/phd/.
 
Application procedure
The application must be submitted in English, by clicking on “Apply online” below and must include the following:  
  • Cover letter detailing your motivation and background for applying for the specific PhD project  
  • CV  
  • Diploma and detailed transcripts of records (MSc and BSc)  
  • Other information for consideration, e.g. list of publications (if any), peer reviewed and other  
  • Personal recommendations (if any)  
  • A maximum of 3 relevant scientific works which the applicant wishes to be included in the assessment (if any)
The deadline for applications is 11 February 2018. Any applications received after this time or incomplete will not be considered.  
 
Receipts of the applications will be acknowledged, and the applicant will be kept continuously informed of the progress of the application.  
 
The further process
Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointment Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk.  
 
Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement.  
 
Please note that the applicant will be contacted if the assessment committee requires further documentation.
 
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.  
 
SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Søren Skov
E-mail: sosk@sund.ku.dk

Info

Ansøgningsfrist: 11-02-2018
Ansættelsesdato: 01-04-2018
Arbejdstid: Fuldtid
Afdeling/Sted: Institut for Veterinær- og Husdyrvidenskab

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