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Postdoc in NEUROEPIGENETICS to Center for Translational Neuromedicine – Division of Cell and Gene Therapy

 

Division of Cell and Gene Therapy is looking for a highly motivated Postdoc. The position is open for one year.

 

Description of our research team

CTN currently has 55 employees and students, divided into two labs. Our group is ambitious, dynamic and international, and we work in a fast-paced working environment.

 

CTN is part of the Faculty of Health and Medical Sciences, University of Copenhagen, and is located at Panum. CTN comprises 2 floors of newly constructed laboratories, and is well-equipped for virtually all capabilities of modern neuroscience.

 

For more information, go to http://ctn.ku.dk/.  

 

Our Group is aimed at defining new strategies for the treatment of neurological and neuropsychiatric disorders. Research focuses on utilizing human pluripotent stem cells as tools to study the biology of neural precursors and glial progenitor cells in both normal and diseased environments. Of particular focus are the myelin disorders (multiple sclerosis, leukodystrophies), and the neurodegenerative disorders, including Huntington’s disease, schizophrenia and frontotemporal dementia. Our research also includes understanding the conversion of glial progenitor cells into glial tumors.

 

Project description

Schizophrenia (SCZ) and Huntington disease (HD) are different disorders that nonetheless share several cardinal features, that suggest common aspects to both their pathogenesis and disease phenotypes. Both are unique to human beings, can manifest with psychosis, involve significant white matter loss, and are characterized by abnormal patterns of gene expression by forebrain glial cells. Recently, both SCZ and HD have been linked to dysmyelination in adult patients; the disease phenotype is associated with a delay in the development of the sole myelin-producing cells of the brain, the oligodendrocytes (OL). The maturation of myelinating OL from their progenitors is a critical step for the myelination during embryonic development and adulthood. During this process, global epigenetic changes take place to achieve the progressive heterochromatinization and the correct nuclear positioning of OL-related genes. The project will aim to get a comprehensive understanding of the epigenetics of OL maturation

 

Qualifications 

We are looking for a highly motivated and enthusiastic postdoc with the following qualifications:
 
  • Candidates must hold a PhD degree in neuroscience or neural cell biology
  • Experience in culturing human stem cells and oligodendrocytes differentiation protocols
  • Experience with epigenetic techniques such as ChIPseq and DNA methylation, ATAC seq will be a plus
  • Experience in FACS sorting
  • The successful candidate must be organized, self-motivated, result-oriented and capable of working independently in a collaborative setting
  • The successful candidate will possess strong written and oral communication skills with the ability to readily learn new experimental techniques.

Terms of employment 

The successful candidate will be offered a full-time 1-year position. The position is covered by the Memorandum on Job Structure for Academic Staff.
 

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

How to apply

Your application must be submitted electronically by clicking "APPLY NOW" below.

 

The application must include:

  • Curriculum vitae
  • MSc and PhD diploma
  • A cover letter describing your research interests and reasons for applying to this position.  

  • A list of publications (or manuscripts) that have been submitted or accepted for publication 

  • Contact information of 2-3 referees

The application deadline is 25 January 2018.

Application procedure 

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

 

 

SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Maria Joana Albuquerque Osório

Info

Ansøgningsfrist: 25-01-2018
Ansættelsesdato: Start hurtigst muligt
Arbejdstid: Fuldtid
Afdeling/Sted: Center for Translational Neuromedicine

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