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PhD fellowship on “Progression and reversibility of NASH induced hepatic fibrosis in vivo” at the LIFEPHARM Centre

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen is offering a PhD fellowship commencing on 1 July 2018 or soon thereafter. The application deadline is 23 May 2018.  
 
The Faculty of Health and Medical Sciences and Novo Nordisk A/S established a research centre in 2010 - The LIFEPHARM Centre (www.lifepharm.dk) - with a budget of DKK 140 million covering activities until the end of 2020.  
 
The present position is part of the Centre´s activities. The purpose of the research centre is to strengthen the research in experimental pharmacology and toxicology and to increase the output of candidates and PhDs with a strong in vivo pharmacological profile.  
 
It is expected that the future PhD fellow will be enrolled in the Graduate Programme for In Vivo Pharmacology and Experimental Animals (IVP) at SUND and participate actively in this network. The IVP Graduate Programme was established in 2006 as a collaboration between the Faculties of Life Sciences, Pharmaceutical Sciences and Health Sciences at the University of Copenhagen, University of Aarhus, and industrial partners; Novo Nordisk A/S, LEO Pharma and H. Lundbeck A/S, www.invivofarm.dk.  
 
For more information on LIFEPHARM or IVP please contact:  
Professor Jens Lykkesfeldt  
Director of LIFEPHARM  
Head of IVP  
jopl@sund.ku.dk  
Phone: (+45) 35 33 31 63  
 
Project background  
Non-alcoholic fatty liver disease (NAFLD) affects around 30% of the population, currently placing NAFLD-associated liver disease as a primary cause of liver transplantation. Though diet is clearly a key-inducer, the factors driving progression from a largely asymptomatic liver steatosis to a clinical manifestation of necro-inflammatory steatohepatitis (NASH) promoting fibrosis and liver damage are not known. The degree of intrahepatic fibrosis is a prognostic hallmark. However, it can currently only be assessed by biopsy at the risk of the patient. Despite increased attention, controlled studies of NASH progression are few and rarely include fibrosis as a primary end-point. Using a validated animal model, we want to provide molecular, biochemical and histopathological insight to the progression and putative pharmacological resolution of fibrosis in NASH, and aim to identify a cluster of markers to predict disease stage – a major unmet need in clinical medicine today.  
 
Principal supervisor  
A/Prof Pernille Tveden-Nyborg  
E-mail: ptn@sund.ku.dk  
Direct Phone: (+45) 35 33 31 26  
Faculty of Health and Medical Sciences  
University of Copenhagen  
 
Co-supervisors  
Markus Latta, Novo Nordisk and Jens Lykkesfeldt, KU  
 
Required qualifications 
  • MSc in a biological science, veterinary medicine, medicine or other equivalent degree  
  • A special interest and competencies within liver disease and animal models  
  • High level of motivation, responsibility and flexibility  
  • Highly enthusiastic, ambitious and team-oriented personality  
  • Excellent communication skills in English (written and oral)  
  • Function ABD/Category C course in carrying out animal experiments  
  • Experience within in vivo pharmacology and animal research  
  • Biochemical and molecular biology laboratory experience  
General Job description  
Your key tasks as a PhD fellow at SUND are to:  
  • Manage, carry through and conclude on your research projects  
  • Actively participate in PhD courses  
  • Write scientific articles and finalise your PhD thesis  
  • Participate in international congresses  
  • Conduct a research stay at an institution abroad  
  • Teach and disseminate your research
We offer 
  • The opportunity to work in a state-of-the-art, highly innovative and scientifically stimulating environment with ambitious colleagues  
  • Excellent training opportunities, both personally and professionally  
  • The opportunity to contribute with new knowledge to an exciting and fast-moving scientific field
Key criteria for the assessment of candidates  
  • The grade point average achieved in relevant University degrees  
  • Professional qualifications relevant to the PhD programme  
  • Relevant work experience  
  • Previous publications  
  • Other professional activities  
  • Language skills
The successful candidate is also required to be resourceful and to possess good interpersonal skills.  
 
Formal requirements
The position is available for a 3-year period for applicants holding a relevant master´s degree.  
  
It is a prerequisite that the PhD candidate is enrolled as a PhD fellow at the Faculty of Health and Medical Sciences, University of Copenhagen according to the rules stipulated in "Bekendtgørelse nr. 18 af 14. januar 2008 om ph.d.-graden." 
 
Terms of employment 
Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. Depending on seniority, the monthly salary begins around DKK 25.141 (ca. 3.374 EUR) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013). 
 
Questions 
For further information contact Pernille Tveden-Nyborg, e-mail: ptn@sund.ku.dk.  
 
Foreign applicants may find the following link useful www.ism.ku.dk (International Staff Mobility). 
 
General information about PhD programmes at the Faculty of Health and Medical Sciences is available on the Graduate School’s website: http://healthsciences.ku.dk/phd/
 
Application procedure 
The application must be submitted in English, by clicking on “Apply online” below and must include the following:  
  • Cover letter detailing your motivation and background for applying for the specific PhD project  
  • CV  
  • Diploma and detailed transcripts of records (MSc and BSc)  
  • Other information for consideration, e.g. list of publications (if any), peer reviewed and other  
  • Personal recommendations (if any)  
  • A maximum of 3 relevant scientific works which the applicant wishes to be included in the assessment (if any) 
The deadline for applications is 23 May 2018. Any applications received after this time or incomplete will not be considered. 
 
Receipts of the applications will be acknowledged, and the applicant will be kept continuously informed of the progress of the application. 
 
The further process 
Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointment Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk
 
Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement. 
 
Please note that the applicant will be contacted if the assessment committee requires further documentation. 
 
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.  
 
 
 
 
SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Pernille Tveden-Nyborg
E-mail: ptn@sund.ku.dk

Info

Ansøgningsfrist: 23-05-2018
Ansættelsesdato: 01-07-2018
Arbejdstid: Fuldtid
Afdeling/Sted: Institut for Veterinær- og Husdyrvidenskab

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