Ph.d.-stillinger – Københavns Universitet

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Ph.D. Fellow in Nutritional Immunology/Parasitology

 
Faculty of Health and Medical Sciences, University of Copenhagen 
 
Department of Veterinary and Animal Sciences (IVH), Section of Parasitology and Aquatic Pathobiology, wishes to appoint a PhD fellow in the area of Nutritional Immunology and Parasitology for three years from May 1st, 2018, or as soon as possible thereafter. 
 
Project description 
The effect of diet on immune function and gut health is of increasing relevance due to rising antimicrobial resistance in livestock production as well as increasing prevalence of chronic inflammation and diet-related disorders in humans. We have found that certain dietary components may reduce inflammation and modulate immune function during infection with gastrointestinal parasites (for more information see http://isim.ku.dk/staff/vip/?pure=en/persons/430773). Here, we will purify bioactive plant compounds and test their activity in vitro cell culture models of inflammation, and in mouse and pig models of gastrointestinal infection with parasitic worms.  
 
Aim 
The PhD fellow will 1) isolate selected dietary components and assess their bioactivity activity using in vitro cell-culture-based assays, transcriptomics and functional cell biology experiments.   
2) Carry out an in vivo studies to assess how bioactive dietary supplements modulate mucosal immune function during colonization with parasitic worms (helminths).  
 
Project organization 
This 3-year PhD study is part of a 4-year project (2018-22) funded by The Independent Research Fund Denmark (IRFD), including the University of Copenhagen, the University of Turku, Finland (UTU), and the University of Wisconsin-Madison, USA. The PhD fellow will be formally enrolled in the PhD programme at the Faculty of Health and Medical Sciences. He/she will be a member of the Veterinary Parasitology Research Group at IVH (http://ivh.ku.dk). 
 
 
Job description 
The PhD fellow will be expected, in collaboration with postdoctoral and senior researchers, to plan and conduct experiments to test immune-modulating activity of a number of bioactive compounds using in vitro cell-based models, and conduct mechanistic experiments to determine how cellular responses are modified using RNA-seq and functional assays. Subsequently, studies will be carried out in mice and pigs (with and without worm infections) to test these immune-modulating effects in vivo. The work will be a close collaboration between IVH and UTU, and the PhD fellow will be required to spend a period of time (around 3 months) at the beginning of the project at UTU, with some shorter additional visits also possible. All costs will be paid by the project. Other visits to collaborators (e.g. for meetings) as well as travel to international conferences, will be required. Full training will be available. The PhD fellow will also contribute to teaching in the section. 
 
Key criteria for the assessment of candidates 
The candidate should have: 
  • Relevant MSc or BSc (hons) degree in the fields of Biology, Biotechnology, Veterinary or Animal science, Parasitology, Biochemistry/Immunology, or other related field  
  • Fluency in written and spoken English 
  • Interest in working with experimental animals 
 
 
Qualification requirements 
Applicants with some or all of the following professional and personal qualifications will be highly advantaged: 
  • Documented laboratory work within immunology, parasitology or other related field including published work  
  • Experience with cell-based assays  
  • Experience or knowledge of HPLC-MS  
  • Experience with standard immunology and/or molecular biology techniques (e.g. flow cytometry, qPCR, Western blotting) 
  • Experience or interest in working with experimental animals 
  • Postgraduate experience 
  • Rich on initiative and strong motivation for research  
  • Excellent communication skills 
  • Well-developed collaborative skills and a team player 
 
Formal requirements  
The position is available for a 3-year period for applicants holding a relevant degree.  
It is a prerequisite that the PhD candidate is enrolled as PhD student at the Faculty of Health and Medical Sciences, University of Copenhagen according to the rules stipulated in "Bekendtgørelse nr. 18 af 14. januar 2008 om ph.d.-graden." 
 
Terms of employment  
Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the Job Structure for Academic Staff at Universities (2013). 
 
Place of work 
The main place of work will be at the Department of Veterinary and Animal Sciences, University of Copenhagen at Frederiksberg Campus. Travel in relation to guest visits or stays at other international research institutions and international conferences will be part of the position as well as meetings in Denmark.  
 
Questions 
For further information about the position, please contact Associate Professor Andrew R Williams by phone (+45-3533 2797 or -31383122) or email (arw@sund.ku.dk). 
 
Foreign applicants may find the following links useful: www.ism.ku.dk (International Staff Mobility) and www.workingconditions.ku.dk 
 
Application 
The application must be written in English and include the following appendices: 
Cover letter, stating your motivation and background for applying for the PhD position. 
Appendix 1: curriculum vitae with documentation of education such as diploma and transcripts of records (BSc and MSc). 
Appendix 2: a complete list of publications if any. 
Appendix 3: references. 
 
In addition to the material that the applicant wishes to have included in the assessment, the Assessment Committee may include further material in their assessment of the applicant. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee.  
 
The application will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities. 
 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointment Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk 
 
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background. 
  
Please submit the application with the required attachments by clicking on "Apply online". Only online applications will be accepted. The closing date for applications is 23.59 p.m. 16th  February 2018.  
 
The Faculty of Health and Medical Sciences comprises approximately 5000 students, 1000 PhD students and 1800 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. 
 
 
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Info

Ansøgningsfrist: 16-02-2018
Ansættelsesdato: 01-05-2018
Arbejdstid: Fuldtid
Afdeling/Sted: Institut for Veterinær og Husdyrvidenskab

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