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Postdoc positions in Proteomics, Epigenetics and Cell Signaling

Two postdoctoral positions are available at the Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk), University of Copenhagen. Salary: ~50,000-54,000€ PA, plus 17.1% in pension contributions.
 
About CPR and the research Group  
The Novo Nordisk Foundation Center for Protein Research (CPR) at the Faculty of Health and Medical Sciences, University of Copenhagen, has been established to promote basic and applied discovery research on human proteins of medical relevance. The Center comprises a wide range of expertise and skills, from proteomics, bioinformatics, high-content microscopy, high-throughput protein production, to functional dissection of complex signaling systems.
 
The “Proteomics and Cell Signaling” group at CPR is led by Group Leader Prof. Chunaram Choudhary. The Choudhary group works closely with other groups at CPR, especially with Prof. Matthias Mann with whose group we share the laboratory space and infrastructure. The group applies cutting-edge mass spectrometry (MS)-based technologies for unbiased identification and quantification of posttranslational modifications, such as ubiquitylation, phosphorylation and acetylation. Using these approaches we study cell signaling at a “systems-level” in response to different perturbations (such as growth factor stimulation, chemical and genetic perturbations etc.). We use CRISPR-based genome editing for mapping protein-protein interactions and for functional investigations of lead hits from proteome-wide screens. In addition to the state-of-the-art mass spectrometry, the laboratory is equipped with the cutting-edge infrastructure for molecular biology, cell biology and biochemistry work.
 
The Center offers the latest technologies and expertise for genome-wide screens, the next-generation nucleic acid sequencing, high-resolution microscopy, live cell imaging, and protein biophysical characterizations. Our group is technically and internationally diverse and embedded in excellent environment for high-quality research and collaboration.
 
The group consistently publishes in top-ranked journals and has outstanding track-record in in training the next generation of researchers. We are now looking for highly motivated and qualified postdoc candidates to join our research group.  
Please find more information about the Group here: www.choudharylab.org
 
Project Description  
The candidates will use a combination of the cutting-edge proteomics and CRSPR-based genome editing methods to investigate the dynamics and functions of ubiquitylation and acetylation in genetically defined cell models. Among other tasks, this will include generation of knockout cell lines, affinity-tagging of endogenous proteins, mass spectrometry-based analysis of protein-protein interactions and proteome-wide quantification of PTMs. The project about acetylation signaling will also include global analysis of transcript abundance (i.e. RNA-Seq) and genome-wide mapping of specific epigenetic marks (i.e. Chip-Seq) using the next generation nucleic acid sequencing technologies. The candidate is expected to apply various biochemical and molecular biology approaches for biological follow-up experiments on novel and interesting findings derived from large-scale proteomic screens.
 
Tentative start date: Summer/autumn 2017.
 
Qualifications  
The candidates should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research, and show good inter-personal and communication skills.  
 
  • The candidates are required to have a PhD or equivalent degree in natural or medical science.  
  • Excellent scientific track-record, including at least one publication as first author in a high-quality, peer reviewed international journal.
  • Expert knowledge in one or more of the following areas would be considered an advantage:  
Analysis of cell signaling with biochemistry and molecular biology approaches  
Genetics and cell biology  
CRISPR-based genome editing  
RNA-Seq, GRO-Seq, Chip-Seq  
Analysis of large-scape proteomic and/or genomic dataset  
Genome integrity, chromatin biology, gene transcription  
  • Prior experience in high resolution mass spectrometry is not essential.  
  • Good communication skills, both oral and written.  
  • An analytical aptitude for devising innovative scientific or technical solutions.  
  • Demonstrate enthusiasm, motivation, flexibility and confidence.  
Place of employment and work  
The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. The research environment at CPR is ambitious and international, with approx. 30 different nationalities currently represented. The Center comprises modern laboratories, supercomputer resources and state-of-the-art facilities within protein science, including microscopy, cryoelectron microscopy, and the next generation sequencing. Seminars with high-profile international speakers and regular internal research seminars are organized at the Center.
 
For more information on working and living in Denmark visit www.ism.ku.dk (International staff mobility) and www.workingconditions.ku.dk
 
Terms of salary and employment  
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is around 32,000-33,700 DKK (around 4,200-4,500 €) plus 17.1 % in pension contribution.
 
The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension will be paid as salary. For more information about the different pension schemes www.ism.ku.dk/onarrival/pension/
 
Duration: The duration of the positions is 2 years with a possible extension for up-to two years (depending on the performance, and previous employment at the University of Copenhagen).  
 
Application procedure  
Your application should be submitted electronically to:  http://employment.ku.dk/faculty/  
 
  1. Your application should include the following documents:  
  2. Cover letter  
  3. Curriculum vitae, incl. educational qualifications, experience and a list of publications where it shows that the candidate has published at least one publication as first author  
  4. Scanned copies of both PhD and MSc/BA certificates. If the PhD degree is not awarded, it is sufficient to mention when the applicant expects to submit thesis, or receive the qualifying degree  
  5. Names and contact details for 2-3 referees  
 
The applicants can submit these materials in the given fields in the online submission system, or the application documents can be combined and submitted as a single PDF file. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements and that do not have a least one publication as first author.  
 
Deadline for application: August 31, 2017  
 
After the expiry of the application deadline, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.  
 
You can read about the recruitment process at www.employment.ku.dk
 
For further information about the position or the process or if you experience any technical difficulty with the online submission system, please contact CPR: jobs@cpr.ku.dk
 
CPR and the University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.
 
SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Chuna Ram Choudhary

Info

Ansøgningsfrist: 31-08-2017
Ansættelsesdato: Start hurtigst muligt
Arbejdstid: Fuldtid
Afdeling/Sted: NNF Center for Protein Research (CPR)

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