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2 Postdoctoral Fellowships in the Control of Gene Regulation in Embryonic Stem Cells and Endoderm at the Novo Nordisk Foundation Center for Stem Cell Biology (DanStem)

Background: 
The Novo Nordisk Foundation Center for Stem Cell Biology – DanStem has been established as a result of a series of international recruitments coupled with internationally recognized research groups focused on insulin producing beta cells and cancer research already located at the University of Copenhagen. DanStem addresses basic research questions in stem cell and developmental biology and has activities focused on the translation of promising basic research results into new strategies and targets for the development of new therapies for cancer and chronic diseases such as diabetes and liver failure. Find more information about the Center at https://danstem.ku.dk/.
 
Our research: 
Our lab is focused on understanding how transcriptional differences arise in stem cell populations, how these networks change and how they become stabilized.  We recently established that the starting pluripotent state (naïve vs primed) influences the type of endoderm induced (Anderson et al, NCB 2017).  We will now seek to understand the molecular basis for this difference at a gene regulatory network level.  Functioning as an interdisciplinary lab, we work to combine knowledge from multiple systems through the combinatorial use of animal models, stem cells and computer modelling.  
 
Project: 
The aim of this project is to study the cellular and molecular mechanisms of endoderm induction, focusing on the networks of enhancers that are available in naïve and primed pluripotent cells and how these enhancers get utilized in differentiation.  There will be two projects; one using mouse genetics to approach this problem and the other in vitro cell culture systems.   
One of the positions is for 2 years and the other is for 3 years with possible extension. The employments are planned to start in the middle of 2018 or upon agreement with the chosen candidate. 
 
Qualifications: 
  • A PhD degree in life sciences.  
  • Documented hands-on experience in developmental biology and genetics of the mouse 
  • Either documented experience in ChIP seq and other NGS technologies or experience with embryo culture.   
  • Good record of peer reviewed scientific publications and grant writing skills. 
  • An interest in cross-disciplinary research. Experience in the same is a merit 
  • Excellent English skills written and spoken 
Employment Conditions:
The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. The position will be at the level of postdoctoral fellow and the basic salary according to seniority is 32.700-34.400 DKK/month. A supplement could be negotiated, dependent on the candidate´s experiences and qualifications. In addition a monthly contribution of 17.1% of the salary is paid into a pension fund. Applicants that are recruited from abroad may be eligible for a special researcher taxation scheme. In all cases, the ability to perform the job will be the primary consideration, and thus we encourage all - regardless of their personal background and status - to apply. 
 
For further information contact Professor Josh Brickman, joshua.brickman@sund.ku.dk 
Foreign applicants may find the following links useful: www.ism.ku.dk (International Staff Mobility) and www.workingconditions.ku.dk
 
Application Instruction:  
The application must be submitted in English, by clicking on “Apply online” below. Only online applications will be accepted. The closing date for applications is 23.59pm, 30 May, 2018. 
 
The application must include:  
  • Cover letter detailing the basis on which the applicant scientific qualifications meet the requirements for this position. 
  • Curriculum vitae. 
  • List of references (full address, incl. email and phone number) 
  • Diplomas – all relevant certificates. 
  • List of publications. 
Application procedure: 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on his/her assessment. You may read about the recruitment process at http://employment.ku.dk. DanStem and The University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates, regardless of personal background.  
 
Apply online 
 
Link for general info on the recruitment process: https://employment.ku.dk/faculty/recruitment-process.
 
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 37,000 students and 9,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. 
SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Joshua Mark Brickman

Info

Ansøgningsfrist: 30-05-2018
Ansættelsesdato: Start hurtigst muligt
Arbejdstid: Fuldtid
Afdeling/Sted: DanStem

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