Postdoc Fellowship in GPCR molecular pharmacology

The Molecular Pharmacology Group (Professor Bräuner-Osborne group), Department of Drug Design and Pharmacology, University of Copenhagen wish to employ a Postdoc in G protein-coupled receptor (GPCR) molecular pharmacology. The position starts 1 March 2019 or soon thereafter and last for 2 years.  
 
Groups 
Professor Hans Bräuner-Osborne, University of Copenhagen (http://drug.ku.dk/research/ep/molecular_pharmacology/) has a strong track record in molecular pharmacological characterization of GPCRs tightly integrated with leading computational drug designers, medicinal chemists and structural biologists. The Postdoc will be co-supervised by Assistant Professor Thor C. Møller whoworks on a closely related project and Associate Professor Jesper M. Mathiesen who has strong experience in protein purification and pharmacological characterization of nanobodies. 
 
Project 
This Postdoc fellowship is financed by a research grant from the Independent Research Fund Denmark - Medical Sciences. The overall objective of the project is to dissect metabotropic glutamate receptor 5 (mGluR5) internalization pathways using genetic and pharmacological tools including pharmacologically active nanobodies. The Postdoc will focus on the role of kinases in internalization of mGluR5 using kinase inhibitors and CRISPR/Cas9 genome edited cell lines (generated by the Postdoc) and a state-of-the-art high throughput real-time internalization assay based on SNAP-tagged mGluR5. In the second part of the project the Postdoc will characterize pharmacologically active mGluR5 nanobodies with respect to biased signaling, endosomal signaling and receptor internalization using a range of signaling pathway assays, the aforementioned internalization assay and confocal microscopy. The latter will include generation of fluorescence labelled nanobodies used to track receptor internalization and via feeding studies.  
 
Qualification requirements 
Mandatory requirements 
  • A PhD degree in the area related to pharmacology, signalling, molecular or cell biology 
  • Solid experience with molecular pharmacology of GPCRs 
  • Demonstrated ability to independently learn new concepts and solve biological problems 
  • Excellent collaboration and communication skills: fluency in English and experience in writing scientific texts  
Additional meriting qualifications 
Experience of, and skills in: 
  • Mammalian cell culture 
  • G protein-coupled receptor pharmacological assay methods 
  • Analysis of biased signaling 
  • Nanobody purification,labeling and characterization 
  • CRISPR/Cas9 genome editing of mammalian cells 
  • Confocal microscopy 
  • Experience with GraphPad Prism software package 
General job description  
Your key tasks as a Post Doctorial fellow at the Faculty are to:  
  • Manage and carry through your research project 
  • Write scientific articles 
  • Participate in the education and guidance of students 
Key criteria for the assessment of applicants 
  • Professional qualifications relevant to the project 
  • Relevant work experience 
  • Publications 
  • Other professional activities 
  • Language skills 
  • Good interpersonal skills 
Terms of employment 
The post will be filled according to the Agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The post is covered by the Protocol on Job Structure for Academic Staff at Universities (2013). 
 
Questions 
For further information about the post, please contact Professor Hans Bräuner-Osborne, hbo@sund.ku.dk   
 
Application 
The application, in English, must be submitted in the online application form. The application must include the following appendices: 
Appendix 1: curriculum vitae with documentation of education. 
Appendix 2: a complete list of publications. 
Appendix 3: documentation of additional research qualifications, incl. letter of recommendations. 
 
Please submit your application no later than 31 January 2019 
 
In addition to the material the applicant wishes to be included in the assessment, the Assessment Committee may include further material in their assessment of the applicant, such as reference letters. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee. No research/project plan needs to be submitted. Following processing of the application, any application material sent will be destroyed. 
 
The further process  
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.  
 
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/      
 
The application will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities. 
 
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone. 
 
University of Copenhagen and Denmark 
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 37,000 students and 9,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more at www.sund.ku.dk and www.drug.ku.dk   
 
Copenhagen is a modern capital with plenty of opportunities in culture, design, architecture, restaurants and a diverse nightlife. At the same time, the city offers beaches, beautiful parks and green nature areas, and the Copenhageners bike everywhere. The Danish society prioritises a good work-life balance, and the work culture is well adjusted for families with children. Read more at http://ism.ku.dk/    
 

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Kontakt

Hans Bräuner-Osborne
E-mail: hbo@sund.ku.dk

Info

Ansøgningsfrist: 31-01-2019
Ansættelsesdato: 01-03-2019
Arbejdstid: Fuldtid
Afdeling/Sted: Department of Drug Design and Pharmacology

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