Postdoc in Synaptic Transmission of Human iPSC-derived Neurons at Department of Neuroscience

Faculty of Health and Medical Sciences

University of Copenhagen

We are looking for a highly motivated and dynamic researcher with interest in synaptic transmission for a 3-year position to start at 1 December 2019 or after agreement.

Background

The position is part of the project “Neurodevelopmental disorders and the synapse” funded by the Lundbeckfonden call “What Causes Brain Disease?”. This is a collaboration with the Danish Epilepsy Hospital Filadelfia (Dr. Elena Gardella and Dr. Rikke Møller), and Vrije Universiteit Medical Center, Amsterdam (Prof. Dr. Matthijs Verhage). The project involves novel human and animal models for neurodevelopmental disorders caused by mutation of the synaptic release machinery, as well as systematic comparison to human patient and EEG data. We want to test specific hypotheses for the etiology of these disorders. We hypothesize that an imbalance in the ratio between excitatory and inhibitory neurotransmission leads to hyperexcitability and Intellectual Disability.

Our research

The Sørensen and Perrier groups are highly interactive and characterized by team work and strong support among team members. The teams are highly interdisciplinary and international and we welcome team members of any nationality, gender and age. Sørensen’s work is focused on understanding the molecular mechanism of synaptic transmission and neurotransmitter release. Work is carried out on neuroendocrine cells and central synapses with a range of methods, including molecular biology, cell biology, superresolution microscopy and electrophysiology/electrochemistry. Information on the Sørensen group can be found on https://in.ku.dk/research/jakob-balslev-soerensen/. The Perrier group has a strong interest in the endogenous properties of neurons and in mechanisms behind epilepsy. Methods used are patch-clamp and 2-photon microscopy on brain slices as well as behaviour. Information on the Perrier group can be found on https://in.ku.dk/research/jean-francois-perrier/. The two groups are located on the same floor of the Mærsk Tower, in the vibrant research environment of Department of Neuroscience. Information on the department can be found at https://in.ku.dk/.

Your job

The specific aim of the current position is to investigate synaptic transmission in human stem-cell derived neurons to identify neurodevelopmental disorder mechanisms.

Together with other group members, your tasks will be to differentiate stemcells to neurons and to perform single or double patch clamp recordings in vitro. You will perform patch-clamp to test synaptic transmission in micronetworks formed in vitro from human iPSC-derived neurons. You will characterize synaptic transmission in excitatory and inhibitory neurons and investigate whether mutations impact differently depending on neuronal type. You will work together with other team members in Copenhagen, Dianalund and Amsterdam to gain a detailed understanding of these disorders.

Profile

We are looking for a highly motivated and enthusiastic scientist with the following competencies and experiences:

Essential experience and skills:

  • You have a PhD in Neuroscience.
  • You have an excellent scientific track records with first-author publications.
  • You are highly experienced in electrophysiology and optical techniques (incl. patch-clamp).
  • You have experience with cell culture methods.
  • You are enthusiastic, highly motivated and a self-starter.
  • Proficient communication skills and ability to work in teams.
  • Excellent English skills written and spoken.

Place of employment

The place of employment is at Department of Neuroscience, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories in the new Mærsk Tower, https://maersktower.ku.dk/

Terms of employment

The employment as postdoc is a full time and fixed-term position for 3 years. Starting date is 1 December 2019, or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,000 DKK/ approx. 4,480 Euro (April 2019-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions

For further information please contact, please contact Professor Jakob Balslev Sørensen jakobbs@sund.ku.dk or Associate Professor Jean-François Perrier perrier@sund.ku.dk.

Foreign applicants may find this link useful www.ism.ku.dk (International Staff Mobility).

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate (if applicable), c) transcripts of records, including courses followed and marks obtained. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

5. Letters of recommendation and the name of at least two references

Application deadline:  4. October 2019, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/  

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

 


SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Jakob Balslev Sørensen

Info

Ansøgningsfrist: 04-10-2019
Ansættelsesdato: 01-12-2019
Arbejdstid: Fuldtid
Afdeling/Sted: Department of Neuroscience

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