Ph.d.-stillinger – Københavns Universitet

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PhD fellow in single molecule biophysics

Department of Chemistry, Faculty of Science at University of Copenhagen is offering a PhD scholarship in Single molecule biophysics commencing 1st February or as soon as possible thereafter. 
Description of the scientific environment 
The position is in the Group of Asoc. Prof Nikos S. Hatzakis at the Department of Chemistry, University of Copenhagen. The main interest of the group is to develop and optimize methods, which through single molecules studies, can provide a fundamental understanding of the molecular mechanistic detail underlying biomolecular recognition and protein function. 
Project description 
The PhD student will be tasked with the development, optimization and use of single particle assays to quantify protein-ligand (oligosaccharides, small molecule inhibitors, protein, mucin) interactions using fluorescent microscopy techniques like TIRF, and confocal microscopy. The project lies in the interface of physics chemistry with an emphasis on glycobiology and medicinal chemistry and requires extensive statistical analysis. The student will aim to quantify protein biomolecular recognition and ligand protein interactions. During the project, the student is expected to both perform advanced single particle experiments and treat the high quality data and as such will be tasked with developing, assessing and optimizing software suitable for treatment of large datasets. The results will be crucial for attaining a fundamental understanding of protein ligand interactions, and utilize this for biosensors, and will be important for applications with industrial partners like Biotech and pharmaceutical companies as well as medical doctors.  
The group currently consist of 10 persons (1 Asoc. Prof, 3 post Docs, 5 PhDs and 3 MSc) 
Principal supervisor is Associate professor, Nikos S. Hatzakis, Department of Chemistry,  Direct Phone: 0045 35334502 
Job description   
The position is available for 3 year (or 4 for the 3+5 applicants) and your key tasks as a PhD student at SCIENCE are:   
•                          To manage and carry through your research project   
•                          Attend PhD courses   
•                          Write scientific articles and your PhD thesis   
•                          Teach and disseminate your research   
•                          To stay at an external research institution for a few months, preferably abroad   
•                          Work for the department   
Formal requirements   
Applicants should either hold or be enlisted on a MSc degree in Physics, Nanoscience, or similar fields with great results and excellent English communication skills.  
In order to be considered for the position the applicants should have : 
  • Extensive expertise in fluorescent microscopy (TIRF and confocal), single particle techniques  
  • Documented experience with writing and understanding scientific software including Matlab and Python for quantitative image analysis, and treating large datasets  
  • Documented experience with multivariate analysis and machine learning methodology 
  • Extensive expertise in protein ligand interactions by single particle tracking studies  
  • Expertise with model membrane systems, such as liposomes , on how to assemble them and image them using fluorescent microscopy 
  • Comprehensive knowledge about protein interactions with liposomes 
  • Fluency in English and excellent communication skills 
  • Documented expertise of working on international multicultural environment  
Terms of employment   
The position is covered by the Memorandum on Job Structure for Academic Staff.   
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.   
The starting salary is currently at a minimum DKK 312.879 including annual supplement (+ pension up to DKK 43.219). Negotiation for salary supplement is possible.   
Integrated MSc and PhD Scheme  
The position is also available for candidates who are (or are eligible to be) enrolled at one of the faculty’s master programmes in in Physics, Nanoscience, or similar fields. The duration of the integrated programme depends on the amount of credits that you have passed on your MSc programme. For further information about the study programme please see:  “Study Structures”. 
Scholarship and terms of employment for integrated MSc and PhD 
PhD grant portions (Ph.D.‐SU klip) 
In the period up to the completion of the MSc programme (up to three years), the student is entitled to so-called PhD grant portions. The grant portions are financed by the grant donor but not by the Danish State Educational Grant and Loan Scheme Agency (as is the case for the ordinary study grant portions on the BSc and MSc programmes). They are called PhD grant portions because this kind of remuneration is regulated and described in the Executive Order on the State Educational Grant and Loan Scheme in Denmark (SU‐bekendtgørelsen), and because the value of a PhD grant portion corresponds to the value of an ordinary Danish study grant portion. Students are awarded 48 PhD grant portions during the period of their MSc and PhD studies. 
48 PhD grant portions at DKK 6.090 each, corresponding to DKK 292.320  
'Duty work' 
As a supplement to the PhD grant portions, the student may, in accordance with the collective agreement of the Danish Confederation of Professional Associations (AC), be offered 'duty work'. In the period up to the completion of the MSc programme, students performing 'duty work' are paid by the hour. UCPH has decided to offer students on integrated MSc and PhD schemes 150 hours of 'duty work' per year during Part A of the programme (until two years of the combined programme of study remain). 'Duty work' during Part A if it has a duration of three years: 450 hours at a rate of DKK 202.64 (+ 12.5% holiday pay), corresponding to DKK 102,586.50. 
For further information about Part A please see:
Salary in accordance with the collective agreement with the Danish Confederation of Professional 
Associations (AC) 
In the period after the completion of the MSc programme, the student is employed as a PhD scholar and is remunerated in accordance with the collective agreement with the Danish Confederation of Professional Associations (AC). The scheme is arranged in such a way that students graduate from the MSc programme at a time when there are two years left of the integrated programme. For this reason, the salary must be paid for a period of two years in accordance with the collective agreement with the Danish Confederation of Professional Associations (AC). The amounts specified include a supplement locally agreed upon as well as pension contributions: Salary as a PhD scholar: 24 months at a rate of DKK 28,955.15 (including pension contributions and supplement), corresponding to DKK 694,923. '
Application Procedure   
The application, in English, must be submitted electronically by clicking APPLY NOW below.   
Please include   
  • Cover Letter, max 0.5 pages detailing your motivation and background for applying for the specific PhD project 
  • CV
  • Diploma and transcripts of records (BSc and MSc) or letter confirming the graduation within 15 days of deadline   
  • Acceptance Letter for the relevant MSc Programme at SCIENCE, if any (for applicant of (3+5) ) 
  • Other information for consideration, e.g. list of publications, patents (if any) 
  • Full contact details (Name, address, telephone & email) of 1-3 professional referees  
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.   
The deadline for applications is December 12th, 2018, 23:59 GMT +1. Applications received after the deadline for applications will not be considered.   
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.   
The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at    
For specific information about the PhD scholarship, please contact the principal supervisor Associate professor Nikos S. Hatzakis, Department of Chemistry  Direct Phone: 35334502.   
General information about PhD programmes at SCIENCE is available at    


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Ansøgningsfrist: 12-12-2018
Ansættelsesdato: 01-02-2019
Afdeling/Sted: Kemisk Institut

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