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Postdoc position in Andersen group at BRIC, University of Copenhagen

We are looking for a highly motivated and dynamic researcher, who have excellent experience in molecular and cellular biology as well as talent for high-throughput and data analyses. 
You will enter an active team focused on elucidating epigenomic deregulation and understanding their causal role(s) in primary liver cancer, impact on tumor cell dissemination and drug response. The position requires skills in primary patient-derived cell and organoid culturing, HTS, epi-CRISPR and informatics.   
 
The Research Centre 
The Biotech Research and Innovation Centre (BRIC) is a research centre of excellence for biomedical research, focusing on disease-oriented basic research, at the Faculty of Health and Medical Sciences, University of Copenhagen.  BRIC hosts 24 independent research groups that perform basic and translational research aimed to understand diseases like cancer, neurological and metabolic disorders. 
For further information about the Andersen group and BRIC: https://www.bric.ku.dk/  
 
Our research 
The focus of our research is translational medicine in primary human liver and biliary tract cancers with emphasis on genome-wide and high-throughput techniques in the characterization of tumor heterogeneity, prognostic and predictive biomarker discovery and drug response, to aid novel therapeutics and clinical efficacy. It is our goal to improve diagnosis, clinical decision-making and ultimately patient outcome through translational and pharmacogenomics discoveries. This is facilitated in our Group via interdisciplinary research (molecular biology, medicine and bioinformatics) as well as a strong national and international network of scientific and clinical collaborators.  
 
This project will apply high-throughput CRISPR screening of prospective epigenetic regulators in sophisticated patient-derived cell models to identify genes with previously unknown epigenome regulatory functions and characterize their roles in hepatobiliary cancer initiation and progression. Such work will shed light on novel genome regulation mechanisms and identify potential therapeutic targets to address key clinical problems, such as chemoresistance and metastasis. 
 
Your job 
You will join a research group where we strive to implement new technologies and utilize these to better understand clinical problem. We use advanced culture methodologies and omics-driven strategies to characterize and classify patient subgroups to identify oncogenic drivers and addiction networks with the aim of improving diagnostics and treatment. We unite research directly on patient samples and clinical data with basic molecular in vitro and in vivo models.  
Your task would to setup a CRISPR screening of epigenetic regulators. Emphasis will be given to a candidate with background within liver cancer research, CRISPR screening and experience in bioinformatics. 
 
Profile 
You have the ability to function and trive in a interdisciplinary and collaborative environment. You are independent and able to envision, plan and execute a research project. We are looking for a highly motivated and enthusiastic scientist with the following competences and experience: 
 
Essential: 
  • You have a PhD or MD/PhD in Molecular medicine or related field 
  • You are highly experienced in molecular and cellular biology 
  • You have an active interest in interdisciplinary translational reseach  
  • Proficient communication skills and ability to work in teams 
  • Excellent English skills written and spoken 
 
Desirable but not required: 
  • Experience/knowledge in bioinformatics applications 
  • Experience/knowledge in liver cancer research (Hepatology)  
 
We offer 
  • A 2 year contract(possibly extendable) with a competitive salary and social benefits (e.g. social security, health coverage, parental leave) 
  • Access to state-of-the art tools and infrastructure  
  • Tailored support in raising competitive funds and communicate your research 
  • A stimulating and supportive international research environment 
We have weekly internal seminars with PhD students and postdocs presenting their work as well as external seminars with international speakers. BRIC also hosts several research clubs; hematology club, Chromosome Biology club, Stem cell club and single cell transcriptomics seminar series. The institute has an association for students and postdocs (ASAP), a PhD programme (MoMeD) and a Postdoc Career Programme (PCP). BRIC has extensive international collaborations and actively participates in the European alliance, EU-LIFE consisting of 13 excellent life science research institutions and is part of the EU-funded LIBRA initiative to obtain gender balance in life science research.
 
BRIC has a highly international profile (over 60% international researchers) and English as working language. An InternationalStaff Mobility Office at UCPH supports and guides international researchers through your initial steps in Denmark (e.g. residence and work permits, tax and pension, banking, medical care, childcare). They also offer a dual career network open for spouses of our researchers. 
 
Start date: August 1st 2018 or after agreement. 
For further information regarding the position, please contact Associate Professor Jesper B Andersen on e-mail: jesper.andersen@bric.ku.dk 
 
Terms of salary and employment 
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 33,224 DKK/ca. 4,430 Euro. An additional 17.1 % monthly contribution to pension will be paid by the employer. Depending on qualifications, a higher salary may be negotiated.
 
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.  
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.  
 
Application 
Your application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on https://www.bric.ku.dk/jobs/. The application must include the following documents/attachments – all in PDF format:
 
1. Motivated letter of application (max. one page). 
2. CV incl. education, work/research experience, language skills and other skills relevant for the position. 
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do. 
4. List of publications. 
 
Letters of recommendation 
Furthermore, the shortlisted applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format and send to jesper.andersen@bric.ku.dk with subject “name candidate-postdoc-2018”; preferably by the supporting person. The letters should be received 1 week after being notified about shortlisting. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.  
 
Application deadline: July 15 2018 
 
We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the abovementioned requirements. 
 
Application procedure 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.  
You can read about the recruitment process at https://employment.ku.dk/faculty/ 
 
BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone. 
 
 
SØG STILLINGEN

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt

Jesper Bøje Andersen

Info

Ansøgningsfrist: 15-07-2018
Ansættelsesdato: 01-08-2018
Arbejdstid: Fuldtid
Afdeling/Sted: BRIC

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