Postdoc in RhoA function in cancer at BRIC, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Postdoc in RhoA function in cancer at BRIC, Faculty of Health and Medical Sciences,
University of Copenhagen, Denmark
We are looking for a highly motivated and dynamic researcher for a 2 year post doc position starting in April 2019 in the Brakebusch lab. The Brakebusch lab is located at the Biotech Research and Innovation Center (BRIC) (www.bric.ku.dk/Research/Brakebusch_Group/), which is a Center of Excellence in biomedical research with around 200 scientists.
Rho GTPases such as RhoA, Rac1 and Cdc42 are important regulators of the cytoskeleton, but also involved in signal transduction processes regulating proliferation, differentiation and survival. An E40Q point mutations in RhoA is considered to be a driver mutation in Head and Neck Squamous Cell Carcinoma and probably also in breast cancer and lung adenocarcinoma. Based on cancer genome analysis and own research with RhoA function in skin tumor, we hypothesize that RhoA E40Q is a partially inactive RhoA mutant with a cancer promoting role in HNSCC.
Aim of this project is to test and validate the tumor promoting role of RHOA E40Q in vivo and in vitro and to investigate the underlying molecular mechanism. RhoA E40Q function in tumor development will be studied using novel genetically modified mice expressing RhoAE40Q, which will be prepared in collaboration with the Transgenic Mouse Core Facility at the University of Copenhagen. This work will help to identify additional drug targets for precision oncology therapy of HNSCC RHOA E40Q patients.
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
- A PhD in biological/biomedical science
- Strong experience in cell culture and molecular biology
- Experience in handling mice
- High interest in cancer research
- Proficient communication skills and ability to work in teams
- Excellent English skills written and spoken
Desirable experience and skills:
- Experience in isolation and culture of primary keratinocytes
- Experience in CRISPR genome editing
Place of employment
The place of employment is at BRIC, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and core facilities and an exciting research environment with ambitious researchers from all over the world.
Terms of employment
The employment as postdoc is a full time and fixed-term position for 2 years. Starting date is April 1, 2020, or after agreement.
Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 33,300 DKK/ approx. 4,590 Euro (October 2019-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the “The Ministerial Order on the Job Structure of Academic Staff at Universities of 11 December 2019".
For further information please contact Cord Brakebusch (email@example.com)
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:
1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.
Application deadline: 21 February, 2020, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
Interviews are expected to be held in week 10.
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.
Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.